Volume 28, Issue S1 537.3
Anatomy
Free Access

Kruppel-like factor-3: role in lipid secretion, transport and beta oxidation (537.3)

Nafla Alnassar

Nafla Alnassar

Department of Cell Biology-Cardiovascular unit, KFSH&RC, Riyadh Saudi Arabia 1, RIYADH, Saudi Arabia

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Ranjit Parhar

Ranjit Parhar

Department of Cell Biology-Cardiovascular unit, KFSH&RC, Riyadh Saudi Arabia 1, RIYADH, Saudi Arabia

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Futwan Al-Mohanna

Futwan Al-Mohanna

Department of Cell Biology-Cardiovascular unit, KFSH&RC, Riyadh Saudi Arabia 1, RIYADH, Saudi Arabia

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Sarwar Hashmi

Sarwar Hashmi

Developmental Biology, Rutgers Center for Vector Biology, New Brunswick, NJ, United States

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Abstract

Lipid metabolic disorder is a critical risk factor for metabolic syndrome,triggering diseases like obesity and diabetes.Obesity raises the risk for many chronic illnesses including diabetes,and heart disease.A unifying view is that insulin resistance,which arises from an excess of body fat,links T2D to obesity.Consistent with this view it has been observed that fat deposition in insulin effector cells decreases their sensitivity to insulin causing insulin resistance.While genetics and environmental components play a major role in the onset of disease caused by fat accumulation.There has been progress in our understanding of metabolic diseases given the complexity of vertebrate systems that employ many factors acting in overlapping and partially redundant pathways.Highly complicated metabolic networks and sensing mechanisms coordinate the flow of fats through synthesis,storage and breakdown pathways and therefore a composite view of nutrient uptake,transport,storage and utilization is required for its understanding.Mammalian Krüppel-like factors KLFs play essential function in over all energy metabolisms.Many important factors controlling energy metabolism are conserved between mammals and C.elegans providing a new and powerful strategy to dissect the role of KLF in molecular pathways involved in fat metabolism.The worm intestine is our model system where genetics,molecular biology,and cell biology are used to identify and understand genes required in fat metabolism.Thus,we have found an important role of worm KLF in FA biosynthesis,mitochondrial proliferation,lipid secretion,and beta-oxidation.We have began to understand the mechanism by which KLF controls these events in lipid metabolism.We have recently observed that worm KLF3 selectively acts on insulin components to regulate insulin pathway activity.There are many factors that control energy metabolism and defects in this control system are implicated in the pathogenesis of human obesity and diabetes.