Physical host-pathogen networks

Abstract

Pathways and complexes can be considered fundamental units of cell biology, but their relationship to each other is difficult to define. Comprehensive tagging and purification experiments have generated networks of interactions that represent most stable protein complexes. We describe this work in various organisms, including budding yeast and in infectious organisms like HIV and TB, and show how the analysis of pairwise epistatic relationships between genes complements the physical interaction data, and furthermore can be used to classify gene products into parallel and linear pathways.