Volume 29, Issue S1 LB240
Nutrition
Free Access

Influence of Metabolic Genotyping on Weight Loss and Body Composition in Women Participating in a 6 Month Diet and Exercise Program: Preliminary Findings

B Sanchez

B Sanchez

Exercise & Sport Nutrition Lab, Texas A&M University, College Station, TX

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A Coletta

A Coletta

Exercise & Sport Nutrition Lab, Texas A&M University, College Station, TX

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E Galvan

E Galvan

Exercise & Sport Nutrition Lab, Texas A&M University, College Station, TX

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R Dalton

R Dalton

Exercise & Sport Nutrition Lab, Texas A&M University, College Station, TX

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A O'Connor

A O'Connor

Exercise & Sport Nutrition Lab, Texas A&M University, College Station, TX

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M Koozehchian

M Koozehchian

Exercise & Sport Nutrition Lab, Texas A&M University, College Station, TX

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A Reyes

A Reyes

Exercise & Sport Nutrition Lab, Texas A&M University, College Station, TX

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C Goodenough

C Goodenough

Exercise & Sport Nutrition Lab, Texas A&M University, College Station, TX

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M Cho

M Cho

Exercise & Sport Nutrition Lab, Texas A&M University, College Station, TX

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Y Jung

Y Jung

Exercise & Sport Nutrition Lab, Texas A&M University, College Station, TX

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K Levers

K Levers

Exercise & Sport Nutrition Lab, Texas A&M University, College Station, TX

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S Simbo

S Simbo

Exercise & Sport Nutrition Lab, Texas A&M University, College Station, TX

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S Springer

S Springer

Exercise & Sport Nutrition Lab, Texas A&M University, College Station, TX

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L Wilkins

L Wilkins

Functional Genetics, Interleukin Genetics, Waltham, MA

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C Rasmussen

C Rasmussen

Exercise & Sport Nutrition Lab, Texas A&M University, College Station, TX

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R Kreider

R Kreider

Exercise & Sport Nutrition Lab, Texas A&M University, College Station, TX

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Abstract

This study examined whether genetic profile influences response to a diet and exercise intervention. 53 sedentary women (38±12 yrs, 80.8±13.9 kg) were randomized to a control group (C) or exercise + diet groups. Those in exercise groups performed circuit resistance-exercise (4 d/wk) and walked (10,000 steps, 3 d/wk). Diets were 1,500 kcal/d with 20:35:45 (CI), 30:25:45 (CII) or 55:30:15 (AHA) percentages of CHO:FAT: PRO. Buccal cheek swabs were obtained at baseline and analyzed for FABP2, PPARG, ADRB-79, ADRB3, and ADRB-46 genes to determine true (T) or false (F) genetic matches to higher CHO or CHO restricted diets. Body weight and DEXA body composition measurements were obtained at 0, 4, 8, 12, 16, 20, and 24 wks. Data were analyzed by MANOVA and are presented as changes from baseline. An overall Wilk's Lambda time x diet (p=0.085) and time x diet x genotype (p=0.102) trend was observed. Univariate analysis revealed significant interaction trends in fat mass (C: 0.39±1.26; CI: T -6.16±5.04, F -1.58±2.22; CII: T -5.03±2.8, F -4.2±3.3; AHA: T -3.60±2.5, F -5.24±4.0 kg, p=0.06) and percent body fat (C: 0.15±1.61; CI: T -4.95±4.26, F -1.44±2.68; CII: T -3.50±3.17, F -4.87±3.08; AHA: T -3.23±2.81, F -4.32±3.43 kg, p=0.10) while weight was not significantly affected (C: 0.92±2.19; CI: T -6.75±6.38, F -2.22±2.37; CII: T -5.64±3.40, F -2.74±4.37; AHA: T -4.36±2.68, F -5.65±4.94 kg, p=0.33). Preliminary findings suggest that women participating in a 6 month diet and exercise program may experience greater changes in body composition when diet type is matched to genetic metabolic profile.