Volume 29, Issue S1 393.4
Nutrition
Free Access

Relationship between Transferrin Receptor and Two Acute Phase Proteins in Women of Reproductive Age

O.Yaw Addo

O.Yaw Addo

RSPH Emory University, Atlanta, GA, United States

PGNB NICHD, Bethesda, MD, United States

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Fayrouz Ashour

Fayrouz Ashour

PGNB NICHD, Bethesda, MD, United States

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Sorrel Namaste

Sorrel Namaste

PGNB NICHD, Bethesda, MD, United States

SPRING HKI, Washington, DC, United States

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Kevin Sullivan

Kevin Sullivan

RSPH Emory University, Atlanta, GA, United States

Nutrition Branch, CDC, Atlanta, GA, United States

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Parminder Suchdev

Parminder Suchdev

RSPH Emory University, Atlanta, GA, United States

Nutrition Branch, CDC, Atlanta, GA, United States

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Zuguo Mei

Zuguo Mei

Nutrition Branch, CDC, Atlanta, GA, United States

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Fabian Rohner

Fabian Rohner

GroundWork Crans-près-Céligny, Switzerland

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Christine Northrop-Clewes

Christine Northrop-Clewes

Consultant, Cambridge, United Kingdom

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Rafael Flores-Ayala

Rafael Flores-Ayala

RSPH Emory University, Atlanta, GA, United States

Nutrition Branch, CDC, Atlanta, GA, United States

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Daniel Raiten

Daniel Raiten

PGNB NICHD, Bethesda, MD, United States

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Abstract

Transferrin receptor (TfR) is a biomarker for iron reported to be less affected by inflammation compared to ferritin. We examined the associations between two acute phase proteins (APP), α-1-acid glycoprotein (AGP) and C-reactive protein (CRP), with TfR. A multi-national database of 8,410 non-pregnant women aged 15-49 y from 6 countries (USA, Laos, Ivory Coast, Cameroon and Papua New Guinea) as part of the Biomarkers Reflecting Inflammation and Nutrition Determinants of Anemia (BRINDA) project was analyzed. Elevated TfR was defined as >8.3 mg/L, elevated CRP >5 mg/L, and elevated AGP >1 g/L.

Prevalence of elevated TfR was 20.0%, ranging from 5.7% in Laos to 33.8% in Cameroon. Correlations between APP and TfR ranged from 0.01 – 0.27. Based on preliminary analyses, women with elevated AGP had a higher prevalence of elevated TfR [overall prevalence odds ratio (POR) 2.0 (95%CI: 1.6–2.5), with the strongest association in Laos where the POR was 3.1(1.5–6.7). Elevated CRP was not associated with elevated TfR in any country, except USA. When modeling both AGP and CRP as predictors, the POR for elevated TfR was higher for AGP but it remained non-significant for CRP. Inflammation, as measured by elevated AGP but not CRP, is associated with TfR in women of reproductive age and thus may overestimate the prevalence of elevated TfR. In this presentation various approaches to account for inflammation in their relationship with TfR will be presented. Funding:Gates Foundation, CDC, GAIN, NICHD.